Synonyms of 'vicissitude'
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If there is a change in something, it becomes different.
They are going to have to make some drastic changes.
Shift is also a noun.
a shift in policy
A variation is a change or slight difference in a level, amount, or quantity.
Every day without variation my grandfather ate a plate of ham.
Thesaurus for vicissitude from the Collins English Thesaurus
variation or mutability in nature or life, esp successive alternation from one condition or thing to another